Oxyfluorfen 97%TC,240g/L EC, 20%EC,24%EC weedicide broadleaf herbicide pesticide agricultural chemicals agroquimicos

                                                                                  Oxyfluorfen

Oxyfluorfen is a selective pre and postemergent herbicide used to control certain annual broadleaf and grassy

weeds in vegetables, fruit, cotton, es ornamentals and on non-crop areas.

It is a contact herbicide and light is required for it to affect target plants .

It is available in emulsifiable concentrate and granular formulations .

Regulatory Status: Oxyfluorfen is a slightly to practically non-toxic compound in EPA toxicity class III . Products containing oxyfluorfen must bear

the Signal Word WARNING on the label because some formulated products may have higher toxicities. It is a General Use Pesticide (GUP).

Chemical Class: Not Available

Introduction: Oxyfluorfen is a selective pre- and post-emergent herbicide used to control certain annual broadleaf and grassy weeds in vegetables, fruit, cotton, ornamentals, and on non-crop areas (e.g. rail- and highway right-of-ways). It is a contact herbicide and light is required for it to affect target plants. It is available in emulsifiable concentrate and granular formulations.

Formulation: It is available in emulsifiable concentrate and granular formulations.

Toxicological Effects:

• Acute toxicity: Oxyfluorfen is practically nontoxic by ingestion, with reported oral LD50 values of 5000 mg/kg in both rats and dogs, and 2700 to 5000 mg/kg in mice [1. The dermal LD50 is greater than 5000 mg/kg in both rats and rabbits, also indicating slight toxicity by this route . It causes no skin irritation in rabbits, no skin sensitization in guinea pigs, and moderate eye irritation in rabbits . However, Goal and other formulations may show severe skin and eye irritant properties, and may be skin sensitizers . The 4-hour inhalation LC50 for the technical product is not available, but that for Goal 1.6E is greater than 22.64 mg/L, indicating practically no toxicity via this route .
• Chronic toxicity: Effects on the liver have been observed in long-term feeding studies with rats, mice, and dogs .
• Reproductive effects: In a developmental study with rats given doses of 10, 100, or 1000 mg/kg/day by gavage, decreased implantation, increased resorption, and lower fetal survival was seen at the 1000 mg/kg level. Toxic effects on the mothers were also seen at this dose . At 5 mg/kg/day, there was decreased survival of fetuses and decreased maternal and fetal weights . It does not appear likely that oxyfluorfen will cause reproductive effects in humans at likely levels of exposure.
• Teratogenic effects: In a developmental study with rabbits, 30 mg/kg/day, the highest dose tested, produced an increase in fused sternal bones in the fetuses as well as toxic effects on the mothers . These data suggest oxyflurofen may have teratogenic effects, but only at very high doses.
• Mutagenic effects: Mutagenicity tests on rats, mice and on bacterial cell cultures have produced mixed results. However, unscheduled DNA synthesis assays have been negative . Due to the conflicting results, it is not possible to determine the mutagenic potential of oxyfluorfen.
• Carcinogenic effects: In a 20-month study with mice fed 0.3, 3, or 30 mg/kg/day, doses at and above 3 mg/kg/day produced non-significant increases in both benign and malignant liver tumors in male mice . No increased tumor formation was seen in female mice at any dose . No carcinogenic effects were observed in a 23-year study with rats fed doses 2 mg/kg/day, nor in dogs at doses of 3 mg/kg/day . These data suggest that oxyfluorfen is not carcinogenic.
• Organ toxicity: The liver appears to be the main target organ, based on long-term feeding studies.

• Fate in humans and animals: Because oxyfluorfen is highly hydrophobic, it may have the potential to bioconcentrate in animal fatty tissues