Mesotrione is a selective, systemic herbicide that belongs to the triketone chemical family. It was originally developed from leptospermone, a natural compound produced by the Callistemon citrinus (bottlebrush) . This plant was observed to naturally suppress surrounding vegetation, which inspired the creation of mesotrione as a synthetic herbicide for agricultural and turf use ​.

Mode of Action
Mesotrione inhibits the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is essential for the biosynthesis of carotenoids—pigments that protect chlorophyll from sunlight. Without carotenoids, the plant loses its green color, turns white or bleached, and eventually dies. The herbicide is absorbed through both foliage and roots and moves systemically within the plant ​.

Applications
• Primary Use: Weed control in maize (corn) and turfgrass.
• Target Weeds: Broadleaf and some grassy weeds such as pigweed, lambsquarters, crabgrass, and foxtail.
• Timing: Can be applied pre-emergence or early post-emergence for best results ​.

Benefits
• Selective: Controls weeds without harming desirable turf or crops.
• Systemic: Absorbed and translocated throughout the plant for thorough control.
• Flexible: Effective at low use rates and compatible with integrated weed management programs ​.

In summary, mesotrione is a powerful, selective herbicide widely used in corn and turf management. Its unique mode of action, systemic movement, and natural origin make it a valuable tool for modern weed control strategies.

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